腾讯会议:305511754
时间:3月30日13:00-14:00
报告人:杨晓飞(西安交大)
报告人简介:杨晓飞,博士,现为西安交通大学电信学部副教授,博士生导师。博士毕业于西安电子科技大学计算机应用技术专业,研究方向为数据挖掘,生物信息学,博士毕业论文荣获2019年西安电子科技大学优秀博士论文,2019年陕西省优秀博士论文。2018年10月-2019年10月在美国杰克逊实验室作访问学者。主要从事多组学数据分析及算法开发,包括基因组组装及注释、结构变异检测算法开发、表观基因组致病模式挖掘、癌症基因组数据分析等研究。主持青年科学基金项目、中国博士后面上项目、陕西省博士后项目、国家科技重大专项(子课题负责人)等项目。发表学术论文20余篇,包括 Science , Genome Biology , Briefings in Bioinformatics 等顶级期刊,所发表论文累计引用500次,最高单篇引用150次(Google Scholar),h-index为11。
题目:The opium poppy genome and morphinan production
摘要:Morphinan-based painkillers are derived from opium poppy (Papaver somniferum L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. Synteny analysis suggests a whole-genome duplication at ~7.8 million years ago and ancient segmental or whole-genome duplication(s) that occurred before the Papaveraceae-Ranunculaceae divergence 110 million years ago. Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provide insight into how this cluster evolved. Paralog analysis identified P450 and oxidoreductase genes that combined to form the STORR gene fusion essential for morphinan biosynthesis in opium poppy. Thus, gene duplication, rearrangement, and fusion events have led to evolution of specialized metabolic products in opium poppy.